Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.

ABSTRACT: Dementia with Lewy bodies (DLB) is marked by multidomain cognitive impairments, with fluctuations in cognition and alertness being among the most common clinical features. Disruptions in functional connectivity are thought to underlie these fluctuations, but it remains unclear whether such patterns are already present at prodromal stages. We investigated the presence of static and dynamic functional connectivity alterations and their contribution to the clinical phenotype of prodromal DLB, and explored their association with declining locus coeruleus integrity, while considering premorbid intelligence (a proxy for cognitive reserve) as a moderating factor. Three groups of participants on the prodromal spectrum were analyzed: 29 healthy controls, 58 cognitively normal subjects with core cli

SUBMITTER: Mitterova K 

PROVIDER: S-EPMC12374355 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature