L-shaped association between fibrinogen to serum albumin ratio and all-cause mortality among critically ill children: a retrospective cohort study.

ABSTRACT: While elevated fibrinogen-to-albumin ratio (FAR) correlates with all-cause mortality in adults, its prognostic value in pediatric intensive care units (PICUs) remains unclear. This study aimed to investigate the association between FAR and in-hospital all-cause mortality in critically ill pediatric patients. We conducted a retrospective cohort study analyzing the PIC database from 2010 to 2018. Blood samples for fibrinogen and serum albumin were collected within 24 h of admission. The primary outcome was 28-day all-cause mortality. We utilized multivariable Cox proportional hazards regression, smooth curve fitting, and Kaplan-Meier survival curves, along with subgroup analyses and a two-piecewise linear regression model to assess associations. A total of 5,087 patients (mean age 1.4 years;

SUBMITTER: He W 

PROVIDER: S-EPMC12374381 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature