The association between plasma and MRI biomarkers in dementia with lewy bodies.

ABSTRACT: The diagnosis of Dementia with Lewy Bodies (DLB) is primarily based on clinical features. The main driver of DLB is alpha-synuclein-related pathology, but cerebrovascular disease (CVD) and Alzheimer's Disease (AD) co-pathologies are often found in patients with DLB. Fluid biomarkers and magnetic resonance imaging (MRI) can provide mechanistic and diagnostic information beyond clinical features. Therefore, the aim of this study was to investigate the association of plasma biomarkers (GFAP, NfL, Aβ42/40, pTau231, pTau181) with MRI markers of neurodegeneration and CVD in DLB and in patients with AD as a control group. We also evaluated the ability of biomarkers and clinical features to discriminate between DLB and AD. We included 134 patients from the European DLB consortium (DLB (n = 92) and

SUBMITTER: Pena-Bautista C 

PROVIDER: S-EPMC12374387 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature