Metabolic syndrome and risk of incident all-cause dementia, Alzheimer's disease and vascular dementia: a systematic review and meta-analysis of longitudinal studies.

ABSTRACT: Metabolic syndrome (MetS) comprises several co-occurring vascular and cardiometabolic characteristics and might represent a novel modifiable risk factor for dementia, though findings remain inconsistent. To clarify this, we conducted a systematic review and meta-analysis of longitudinal studies investigating the association between MetS with risk of incident all-cause dementia, Alzheimer's disease and vascular dementia. We searched Medline, Embase and PsycINFO databases (from inception to Feb 19th, 2024) for longitudinal cohort studies investigating the association of MetS with incident all-cause dementia or key subtypes, including Alzheimer's, vascular, Lewy Body or other dementias. Random-effects models were used to estimate pooled hazard ratios (pHR) and 95% confidence intervals (CI). R

SUBMITTER: Qureshi D 

PROVIDER: S-EPMC12374402 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature