STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences.

ABSTRACT: As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. We systematically investigated the expression patterns and prognostic relevance of STAT1 isoform-specific transcripts across pan-cancer tissues, with a particular focus on ovarian cancer (OV), and elucidated their potential mechanisms in modulating the tumor immune microenvironment (TIME) to influence patient prognosis. Integrated analysis of the GTEx and TCGA databases was conducted to systematically evaluate the transcript expression profiles of STAT1 isoforms across 32 cancer types and 29 normal tissues. Clinical prognostic significance was analyzed using Cox proportional hazards regression models, complemented by multi-omics approaches i

SUBMITTER: Lan N 

PROVIDER: S-EPMC12374463 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature