The ROS-FOXO pathway mediates broad-spectrum detoxification of acaricides in Tetranychus cinnabarinus.

ABSTRACT: Arthropods have evolved advanced metabolic detoxification pathways that have helped them adapt to complex stresses induced by plant secondary metabolites and synthetic pesticides. Nonetheless, how xenobiotics induce the suite of intracellular metabolic changes important for detoxification in arthropods remains unexplored. In this study, we found that the ancient oxidative stress signaling pathway has adapted to transmit the detoxification signal in T. cinnabarinus, where accumulation of reactive oxygen species (ROS) plays a crucial role in initiating detoxification metabolism. Acaricides exposure led to ROS accumulation, resulting in the activation of Forkhead box O (FOXO) that in turn upregulates the expression of downstream xenobiotic sensors, including CncC, AhR, and HR96. These xenobio

SUBMITTER: Wen X 

PROVIDER: S-EPMC12375005 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature