KLK5 and KLK7 drive cervical carcinoma via KLK14-dependent RhoA and NF-κB pathways.

ABSTRACT:

Background

The global prevalence of Human Papillomavirus (HPV) infection is approximately 12%, which significantly contributes to the development of cervical cancer as HPV is a key driver of tumorigenesis. However, the precise mechanisms by which HPV promotes carcinogenesis and the involvement of additional components in this process remain poorly understood.

Objective

Given the evidence supporting the critical role of serine proteases in carcinogenesis, we investigated their contribution to cervical cancer development in the context of HPV-mediated carcinogenesis.

Methods

Human biopsies were analyzed to assess the expression of serine proteases, including matriptase, kallikrein 5 (KLK5), and kallikrein 7 (KLK7), as well as their endogenous inhibitors. Mechanistic stu

SUBMITTER: Vieira GV 

PROVIDER: S-EPMC12375203 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature