Associations of loneliness and depression with increased risks of incident dementia: A prospective study from three older adult cohorts.

ABSTRACT:

Background

Loneliness is often accompanied by depression and is associated with an increased risk of dementia. However, evidence remains limited regarding how loneliness and depression jointly relate to future dementia risk, and whether depression may help explain the observed association between loneliness and dementia.

Method

We conducted a study using prospective cohort data from three multinational populations. The association between loneliness, depression, and dementia risk was evaluated using Cox proportional hazards models. Mediation analysis was conducted to evaluate the potential contribution of depression to the observed association between loneliness and dementia risk. Additionally, both multiplicative and additive interaction methods were employed to assess the

SUBMITTER: Wang L 

PROVIDER: S-EPMC12375236 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature