Notch-activated basophils support intestinal CD4⁺ T cell fate and function during Trichuris muris infection.

ABSTRACT: Helminth infections affect billions of people worldwide and cause substantial morbidity. Intestinal helminth infection provokes Type 2 inflammation orchestrated by CD4⁺ T helper type 2 (Th2) cells. Th2 cells cooperate with group 2 innate lymphoid cells (ILC2s) to produce interleukin (IL)-4 and IL-13 that prompt an epithelial "weep and sweep" response to drive parasite clearance. Tissue-specific cues optimize CD4⁺ T cell responses, but the mechanisms regulating intestinal Th2 responses remain unclear. Previously, we identified that the Notch signaling pathway in basophils, rare granulocytes, drove effective parasite clearance and an optimal Th2 response during Trichuris muris infection, a mouse model of human whipworm infection. Here we report that basophil-intrinsic N

SUBMITTER: Webb LM 

PROVIDER: S-EPMC12375385 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature