In vivo aortic elasticity measurement using electrocardiogram-gated computed tomography: validation with ex vivo loading test.

ABSTRACT:

Objectives

Aortic aneurysm size is a key determinant for surgical intervention, but aortic catastrophes can occur before reaching the size criteria, indicating size alone is insufficient for risk assessment. Aortic mechanical properties could be another factor for predicting such catastrophes. However, its estimation in daily clinical settings remains impractical. This study aimed to validate a noninvasive electrocardiogram-gated computed tomography (EGCT)-based method for assessing aortic mechanical properties by comparing its measurements with ex vivo tensile testing of resected specimens.

Methods

We analysed 49 patients who underwent surgical repair of the ascending aorta. The mechanical properties of the aortic wall were assessed using two parameters: elastic modulus (E)

SUBMITTER: Yokota J 

PROVIDER: S-EPMC12375406 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature