Inter-rater reliability of atherosclerotic plaque enhancement on 7 T vessel wall MRI: Comparison with quantitative analysis.

ABSTRACT: ObjectiveIntracranial plaque enhancement (IPE) is a potential biomarker of plaque vulnerability but lacks a standardized definition. While subjective assessment may be prone to observer variability, a voxel-based quantification method can detect subtle signal intensity (SI) changes. This study aimed to compare the inter-rater reliability of subjective IPE evaluation with that of a voxel-based quantification method.MethodsPatients with stroke due to intracranial atherosclerosis were prospectively imaged using 7 T vessel wall magnetic resonance imaging. Two adjudicators independently assessed IPE, with discrepancies resolved by a third, experienced neuroradiologist. IPE distribution was quantified using a semiautomated method based on SI measurements from post-contrast T1-weighted images. Th

SUBMITTER: Dier C 

PROVIDER: S-EPMC12375601 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature