Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas.

ABSTRACT:

Background

Early-onset preeclampsia (EOPE) is a severe form of preeclampsia that mainly contributes to maternal and perinatal morbidity and mortality worldwide. This study aimed to systematically analyze the expression and function of ferroptosis-related gene HILPDA in EOPE placentas.

Methods

We included five transcriptomic datasets (GSE148241, GSE44711, GSE74341, GSE114691, GSE10588) downloaded from the Gene Expression Omnibus (GEO) in this study. Using differential expression analysis, weighted gene co-expression network analysis (WGCNA), and machine learning models (LASSO, SVM-RFE, Random Forest), We identified hub genes and diagnostic biomarkers. We performed functional enrichment (GO and KEGG) and immune infiltration analysis to elucidate molecular mechanisms. Experimen

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12375643 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature