Combined in vivo and silico assessment of melatonin's protective effects on rifampicin-induced liver damage in rats.

ABSTRACT: Liver injury is a globally serious problem that may be observed post-chemotherapeutic administration in chronic crises such as tuberculosis (TB). Rifamycin (RIF), particularly, is an indispensable treatment regimen for TB with a significant negative hepatic impact. Therefore, this research aims to assess the restorative role of melatonin (MEL) against rifampicin (RIF)-associated hepatic damage in rats. Moreover, to investigate the ultimate mechanism of the antioxidant potential of MEL with multimodal assessment and in silico molecular conformation. Adult male Wistar albino rats were weighed and divided into four groups of ten rats each. The control group received the vehicle (0.5 ml/day), the RIF-intoxicated group (100 mg/kg/day orally), the MEL-treated group (10 mg/kg/day intraperitoneall

SUBMITTER: Abo-El-Sooud K 

PROVIDER: S-EPMC12375711 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature