Survival impact of adjuvant radiotherapy in early stage low risk elderly male breast cancer patients treated with breast conserving surgery.

ABSTRACT: Our study aimed to evaluate the survival impact of adjuvant radiotherapy (RT) following breast-conserving surgery (BCS) in elderly male patients with early-stage, low-risk breast cancer (node-negative, HR+), and to identify RT-benefiting subgroups using machine learning and causal inference approaches. We conducted a retrospective cohort study using Surveillance, Epidemiology, and End Results (SEER) database (2000-2021), including 360 patients after propensity score matching (PSM). Patients were grouped by RT and non-RT (NRT) status, and a 1:3 nearest neighbor PSM was applied. Overall survival (OS), relative survival (RS), standardized mortality ratio (SMR), and transformed Cox regression were used to estimate RT benefit. Additionally, machine learning models, including random forest, supp

SUBMITTER: Xu C 

PROVIDER: S-EPMC12375713 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature