Single-cell transcriptome sequencing reveals tumor stem cells and their molecular characteristics in intrahepatic cholangiocarcinoma.

ABSTRACT: Intercellular communication signals in the tumor microenvironment are closely related to behaviors such as cancer cell proliferation and immune evasion. However, the specific roles of intercellular signaling pathways in intrahepatic cholangiocarcinoma (ICC) have not yet been fully characterized. In this study, we analyzed publicly available single-cell RNA sequencing (scRNA-seq) data derived from paired samples of two intrahepatic cholangiocarcinoma (ICC) tissues and two adjacent normal tissues, thoroughly examining their cellular composition. InferCNV analysis was employed to compare tumor cells and normal cells, and pseudotime analysis was used to identify the growth and differentiation trajectories of the cells. Additionally, intercellular communication analysis was conducted to elucida

SUBMITTER: Gu X 

PROVIDER: S-EPMC12375763 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature