Polydopamine-coated double emulsion capsules for on-demand drug release with reduced passive leakage.

ABSTRACT: Double emulsions (DEs) are widely explored in pharmaceuticals due to their ability to encapsulate both hydrophilic and hydrophobic drugs. However, their inherent instability limits their effectiveness in controlled drug delivery. Double emulsion capsules (DECs), formed by encapsulating DEs within a polymer shell, improve structural stability but still suffer from unintended drug diffusion due to the porous nature of polymeric shells. Polydopamine (PDA), a bioinspired polymer known for its strong adhesion, biocompatibility, and chemical stability, is a promising coating material for biomedical applications. However, research on its coating on DECs and its potential impact on passive leakage remains underexplored. Here we report PDA-coated DECs as an on-demand drug release system. The PDA co

SUBMITTER: Lee H 

PROVIDER: S-EPMC12375795 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature