The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes.

ABSTRACT: Various genetic aberrations are suggested to initiate the development of acute lymphoblastic leukaemia (ALL) but alone are insufficient for disease onset. Epigenetic alteration, such as DNA methylation changes, plays a key role in human health. Evidence suggests DNA methylation may be an intermediate mechanism through which the environment contributes to ALL manifestation. ALL is categorized into subtypes based on leukaemia-associated genetic events, and it is plausible that different exposures pose differing risks for given subtypes. Using our previously established meet-in-the-middle approach, we performed CpG-level analysis to investigate DNA methylation as an intermediate mechanism between risk exposures and ALL. Differentially methylated CpGs (DMCs) were integrated, identifying overla

SUBMITTER: Saville JR 

PROVIDER: S-EPMC12375842 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature