Impact of PNPLA3 I148M on Drug-Induced Hepatocellular Liver Injury: A Systematic Review and Meta-Analysis.

ABSTRACT: The role of the patatin-like phospholipase domain-containing protein 3 (PNPLA3)-I148M variant in drug-induced liver injury (DILI) remains unclear. This systematic review with meta-analysis investigated whether carriage of PNPLA3 I148M may contribute to the development of hepatocellular DILI. Scientific databases were searched up to January 31st, 2025 for studies investigating serum transaminase elevations in response to drug treatment. Studies were included if serum transaminases were elevated in at least one genetic subgroup (II/IM/MM), and the possible presence of relevant hepatocellular DILI was estimated based on Hy's law. The meta-analysis reported on any increase in transaminases compared to baseline levels. Eight articles covering thirteen studies with a total of 8235 patients were

SUBMITTER: Gatzios A 

PROVIDER: S-EPMC12375943 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature