Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma.

ABSTRACT: Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor chromosome region maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition can simultaneously disrupt multiple key oncogenic drivers. Herein, whether chromenone derivatives, known for detecting thiol-containing molecules, can function as CRM1 inhibitors is explored. Several chromenone-based derivatives are synthesized and it is demonstrated that they inhibit CRM1-driven nuclear export in a structure- and dose-dependent manner. A preliminary structure-activity relationship is established, providing a rationale for s

SUBMITTER: Princiotto S 

PROVIDER: S-EPMC12376248 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature