Palladium-Catalyzed Non-Directed C─H Functionalization of Arenes with Trifluoromethylated Olefins.

ABSTRACT: Herein, we report the palladium-catalyzed non-directed C─H functionalization reaction of simple arenes with α-trifluoromethyl styrene derivatives. The application of 2-pyridone ligands increased the yield and selectivity of the alkenylation reaction and enabled a broad scope of different simple arenes and α-trifluoromethyl styrenes (25 examples, up to 94% yield). Overall, a robust reaction is developed as described by a sensitivity screening. Detailed experimental studies on the reaction were performed to further understand the mechanism. Palladium-catalyzed non-directed C─H alkenylation of simple arenes with α-trifluoromethyl styrene derivatives is accomplished using 2-pyridone ligands, which significantly enhances both yield and selectivity. This approach enables efficient functionalizat

SUBMITTER: Stockmann L 

PROVIDER: S-EPMC12376254 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature