Consensus on core domains for hand eczema trials: Signs, symptoms, control and quality of life.

ABSTRACT:

Background

Hand eczema (HE) is a common and complex skin disease. A uniform set of core outcomes and related measures for use in clinical trials is lacking, making it difficult to compare results across HE studies.

Objective

To reach consensus on a set of core domains and subdomains that should be measured in future therapeutic HE trials.

Methods

In 2024, we conducted a two-round online Delphi (eDelphi) survey among international HE experts, including physicians, patients and their relatives, researchers and industry representatives. A domain/subdomain was included in the core set when ≥80% of participants rated is as 'critically important'; 50% agreement or less resulted in its exclusion. Results from 50% to 80% were deemed controversial and subject for further discu

SUBMITTER: Ronsch H 

PROVIDER: S-EPMC12376261 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature