Novel and optimized diagnostics for pediatric TB in endemic countries: NOD-pedFEND study protocol.

ABSTRACT: Pediatric tuberculosis is a major global public health challenge, with reliable diagnosis being a main obstacle to identifying and treating affected children. New and improved diagnostics, ideally on non-sputum samples, are urgently required, especially in the most vulnerable group of children under five years of age. Studies to date have been limited by small sample sizes and few bacteriologically-confirmed cases. Here, we describe the study protocol of the NIH-funded NOD-pedFEND study, which will be one of the largest diagnostic studies to date of children at greatest risk of tuberculosis. In this prospective observational cohort study, we aim to evaluate existing and novel diagnostic assays, including pathogen- and host-based tests and combinations of tests. A consecutive cohort of chil

SUBMITTER: Song R 

PROVIDER: S-EPMC12376364 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature