Astrocytic ET-1 System Determines Microglia Phenotype Following Spinal Cord Injury.

ABSTRACT: Microglia/macrophages accumulate at the lesion site by switching toward pro-inflammatory (M1)-dominant phenotype at the acute phase following spinal cord injury (SCI). Such biased polarization shapes the functional outcomes by expanding tissue damage. In the present study, the astrocytic endothelin-1 (ET-1) system is revealed to be immediately activated after SCI, driving microglia polarization toward M1, but suppressing toward M2 phenotype through activation of transcription coactivator YAP via ET_A and ET_B receptors. In addition, the activation of astrocytic ET-1 system results in elevation of blood plasma ET-1 level, suggesting a high diagnostic value. SCI-induced thrombin is pinpointed as a crucial activator of the astrocytic ET-1 system. The serine protease dramat

SUBMITTER: He B 

PROVIDER: S-EPMC12376558 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature