Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice.

ABSTRACT: Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high-risk populations and exploring effective prevention and treatment strategies. In a nationwide multicenter prospective cohort study combined with an RCT study, it is found that indexes of muscle health reveal a strong predictive relationship with cognitive performance assessed using the Montreal Cognitive Assessment (MoCA). Furthermore, Random Forest models suggest that lecithin can predict both diseases. Erythrocyte lipid analysis and RCT study indicate the protective function of lecithin and the potential involvement of irisin in that process. In rodent models, phosphocholine (PC) alleviates learning and memory impairments and muscle attenuation in SA

SUBMITTER: Wang X 

PROVIDER: S-EPMC12376584 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature