Molten-Salt-Mediated Synthesis of Atomic Manganese/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti-Osteoarthritis Treatments.

ABSTRACT: Osteoarthritis (OA) is a chronic progressive joint disease characterized by cartilage degeneration and local inflammation, and its progression is closely related to the excessive production of reactive oxygen species (ROS). Despite progress made with small molecule antioxidants and nanozymes, effective antioxidant therapy for the long-term elimination of these ROS remains challenging, largely due to the rapid clearance of antioxidants from the joints via synovial vessels and lymphatics. Herein, a molten-salt method is developed to facilitate the atomic dispersion of Mn or Co ions homogeneously on the surface of akermanite microparticles (AKT-MPs). The micrometer-scale Mn- or Co-AKT-MPs with multi-mimetic enzyme effects are demonstrated to obliterate multiple ROS, thereby protecting the inh

SUBMITTER: Deng R 

PROVIDER: S-EPMC12376603 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature