Prognostic value of the co-stimulatory molecule OX40 expression in Extranodal Natural Killer/T-cell Lymphoma.

ABSTRACT: To explore the clinicopathological features and the prognostic values of the co-stimulatory molecules OX40 and the inducible T-cell co-stimulator (ICOS) in Extranodal Natural Killer/T-cell Lymphoma (ENKTL). 82 participants (median age 51 years, 26.8% female) were included in this study. OX40 and ICOS expression was detected using immunohistochemistry on paraffin‑embedded sections. The level of OX40 and ICOS expression was categorized into negative (0%, no staining) and positive groups. Kaplan-Meier analysis was used to estimate the probability of survival rates, and group comparisons were made using the Log-rank test. Positive staining for OX40 and ICOS was observed in 64 (78.0%) and 48 (58.5%) cases, respectively. The main differences between OX40-positive and OX40-negative were in the Ch

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12377112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature