Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma.

ABSTRACT: Renal cell carcinoma (RCC) is a malignant tumor originating from the renal tubular epithelium and is the 14th most common cancer worldwide, causing around 180,000 deaths annually. Clear cell renal cell carcinoma (ccRCC) is the predominant subtype, accounting for 70-80% of cases. The potential of the leukocyte immunoglobulin-like receptor (LILR) family members in tumor progression and immune evasion has garnered significant attention. To construct a prognosis signature based on the LILR family in ccRCC patients, and explore its relationship with clinical pathological features, immune microenvironment, and drug sensitivity. We analyzed the expression and prognostic value of the LILR family in ccRCC, developed a risk scoring model, and examined its correlation with clinical features, immune i

SUBMITTER: Wei H 

PROVIDER: S-EPMC12377148 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature