Multi-modal proton and sodium MRI for outcome prediction in mild traumatic brain injury.

ABSTRACT:

Objectives

In mild traumatic brain injury, imaging biomarkers are needed to support clinical management. In four antecedent publications, we used two new (sodium and fingerprinting) and two established (spectroscopy and diffusion) MR techniques in a longitudinally followed patient cohort. Here we report final results and combine all data to determine which marker(s) from the four modalities offer the greatest utility for detecting injury and predicting outcomes. We also leverage the independent specificities offered by each modality to explore injury mechanisms.

Materials and methods

The longitudinal spectroscopy data were analysed to complete a full data set of proton (spectroscopy, fingerprinting, diffusion) and sodium MRI, acquired alongside symptomatic, cognitive, and fu

SUBMITTER: Chen AM 

PROVIDER: S-EPMC12377191 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature