Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis.

ABSTRACT: SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has led to millions of cases of Long COVID worldwide. Long COVID is a phenomenon characterized by persistent and debilitating mental and physical symptoms following acute infection. Despite ongoing research, trials, and considerable progress in understanding Long COVID, its exact causes remain only partially understood, with current hypotheses addressing specific aspects of the condition. We conducted one of the most comprehensive meta-analyses to date of all quality bulk RNA-seq studies worldwide from the COVID-19 pandemic and show significant mitochondrial transcript changes in the peripheral immune system of people with Long COVID, with unexpectedly low levels of intracellular viral RNA in Long COVID. This extensive analysis,

SUBMITTER: Maison DP 

PROVIDER: S-EPMC12377506 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature