Human ectodermal organoids reveal the cellular origin of DiGeorge Syndrome.

ABSTRACT: Neurocristopathies account for half of all birth defects and several cancers highlighting the need to understand early neural crest (NC) development, for which suitable human models don't exist. Here, we present a pluripotent-stem-cell-based 3D ectodermal organoid model that faithfully recapitulates early ectodermal patterning of future central nervous system, epidermis and cranial and trunk NC, as well as a diverse selection of NC derivatives -offering a comprehensive platform to study neurocristopathies from early induction of pluripotent-like stem cells at the neural plate border to differentiated cells. DiGeorge syndrome (DGS) is caused by a hemizygous microdeletion of ~fifty genes, many of which play broad roles during embryogenesis. While DGS is traditionally considered to originate

SUBMITTER: Taroc EZM 

PROVIDER: S-EPMC12377509 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature