Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases.

ABSTRACT: The meninges serve as a critical interface between the peripheral immune system and the central nervous system, playing a crucial role in maintaining parenchymal homeostasis. Neurodegenerative disorders, such as amyloidosis and tauopathies, are marked by the accumulation of extracellular neurotoxic amyloid-β (Aβ) plaques and intracellular tau tangles, respectively, leading to neuronal cell death and cognitive decline. The role of the adaptive immune response in these pathologies remains under debate. Adaptive immune cells can manifest as ectopic lymphoid structures (ELS), which resemble secondary lymphoid organs, and form at sites of inflammation or pathology. While ELSs can support immune responses against infections or tumors, they may also have detrimental effects in certain pathologica

SUBMITTER: Fruitman Davidi A 

PROVIDER: S-EPMC12377736 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature