Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults.

ABSTRACT: Oral nicotine pouches may have potential for smoking cessation, but scientific evidence on the effects of pouches and their constituents on smoking behaviour is limited.

Design

This study was a 4-week, open-label, randomised pilot trial of nicotine pouches in 3 mg (low) or 6 mg (high) nicotine strength.

Subjects

US outpatient research clinic with non-treatment seeking adults who smoke cigarettes (N=30).

Interventions

Participants selected two flavours and were instructed to switch to using nicotine pouches in place of cigarettes.

Main outcome measures

We compared groups on cigarettes smoked per day, pouch use and urinary levels of a tobacco-specific carcinogen (NNAL) over 4 weeks, biochemically verified 7-day point prevalence smoking abstinence at week 4, and wi

SUBMITTER: Fucito LM 

PROVIDER: S-EPMC12377922 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature