Pancreatectomy with arterial resection following neoadjuvant FOLFIRINOX: A single-institution experience.

ABSTRACT:

Backgrounds/aims

Arterial resection in pancreatic cancer remains controversial. This study evaluates outcomes of pancreatic resection with arterial involvement following neoadjuvant chemotherapy.

Methods

Retrospective analysis of 100 pancreatic adenocarcinoma patients undergoing resection after neoadjuvant FOLFIRINOX (2010-2024): 26 with arterial resection (ArP), 39 with portal-venous resection (PoP), and 35 without vascular involvement (NoP). Primary outcomes included perioperative morbidity, mortality, and survival.

Results

ArP patients had significantly more stage III disease (73.1% vs 58.9% vs 28.6%, p < 0.001) but achieved acceptable R0 resection rates (76.9% vs 84.6% vs 91.4%, p = 0.04). ArP procedures required longer operative time (386 ± 71 minut

SUBMITTER: Kanani F 

PROVIDER: S-EPMC12377994 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature