Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis.

ABSTRACT:

Background

A method for predicting ulcerative colitis (UC) onset has not been established. Serum autoantibodies have been suggested as potential predictive biomarkers for UC onset. We aimed to validate the risks associated with serological and environmental factors and construct a model for predicting UC development.

Methods

Using the population-based cohort studies (n > 83,000), we identified 42 individuals who were diagnosed with UC later in life and compared them with matched healthy controls. We analyzed serum anti-integrin αvβ6 antibody (anti-αvβ6) and anti-endothelial protein C receptor antibody (anti-EPCR) titers, and lifestyle and dietary habits to explore UC onset predictors. The predictive performance of the models was evaluated based on these predictors.

Result

SUBMITTER: Sawahashi M 

PROVIDER: S-EPMC12378132 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature