(+)-/(-)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Ormosia henryi Prain.

ABSTRACT: Two pairs of undescribed alkaloid enantiomers, (+)-/(-)-ormohenins A (1) and B (2), were isolated from the seeds of Ormosia henryi Prain, along with four undescribed alkaloids (3, 4, 7 and 8) and seven known ones (5, 6, 9-13). Compounds 1-6 belong to the ormosanine-type alkaloids, compounds 7, 9, and 11 are of the lupinine-type, compounds 8 and 10 are classified as anagyrine-type alkaloids, 12 and 13 are cytisine-type alkaloids. The chemical structures of 1-13 were elucidated through comprehensive NMR and MS data analyses. Furthermore, the racemates (±)-1 and (±)-2 were successfully resolved into their respective optically pure enantiomers using a chiral HPLC system. The absolute configurations of compounds 1-3 were determined using single-crystal X-ray diffraction and corroborated by DFT

SUBMITTER: Cheng M 

PROVIDER: S-EPMC12378240 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature