Cerebral glucose delivery, transport and metabolism: Theory and modeling using four, three, and two tissue compartments.

ABSTRACT: Flux equations describing brain D-glucose uptake are presented for up to four tissue compartments: blood, endothelial intracellular space in the blood-brain barrier (BBB), extravascular-extracellular space (EES), and intracellular space. Transport rates are described by Michaelis-Menten kinetics, including half-saturation constants (KT) and maximum rates for transport (Tmax) over the BBB and the cell membrane (CMB). These transport parameters and the maximum rate for hexokinase-catalyzed metabolism (VmaxHK) were determined by numerical fitting of the models to both steady-state and dynamic D-glucose uptake data in human gray matter from MRS. Two-, three-, and four-compartment results are compared, including effects of incorporating an endothelial compartment with unequal ratios (RA/L) of G

SUBMITTER: Seidemo A 

PROVIDER: S-EPMC12378249 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature