A type of pancreatic cancer cells form cell clusters from a solitary condition in a primary ciliogenesis-dependent manner.

ABSTRACT: Primary cilia are hair-like projections that protrude on most of mammalian cells and mediate reception of extracellular signals. Numerous studies have demonstrated that a variety of cancer cells including pancreatic ductal adenocarcinoma (PDAC) fail to form primary cilia. The loss of primary cilia is thought to cause carcinogenesis and progressive cell proliferation. However, the relationship of the primary cilia loss with carcinogenesis and/or cancer malignancy remains arguable. We herein examined whether ciliogenesis was increased in a model of more progressive PDAC and investigated effects of ciliogenesis on growth of PDAC using a pancreatic cancer cell line, PANC-1. The majority of PANC-1 cells in a cell cluster grown from a solitary cell possessed primary cilia. The rate of ciliogenes

SUBMITTER: Shirakawa K 

PROVIDER: S-EPMC12378286 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature