Evaluating the use of lanthanide containing dendrimers for solvent paramagnetic relaxation enhancement.

ABSTRACT: Paramagnetic relaxation enhancement (PRE) is widely used in biomolecular NMR spectroscopy to obtain long-range distance and orientational information for intra- or intermolecular interactions. In contrast to conventional PRE measurements, which require tethering small molecules containing either a radical or paramagnetic ion to specific sites on the target protein, solvent PRE (sPRE) experiments utilize paramagnetic cosolutes to induce a delocalized PRE effect. Compounds developed as contrast agents in magnetic resonance imaging (MRI) applications typically consist of Gd chelated by a small molecule. Coordinating these Gd-containing small molecules to larger and inert scaffolds has been shown to increase the PRE-effect and produce more effective contrast agents in MRI. Inspired by their us

SUBMITTER: Pawloski W 

PROVIDER: S-EPMC12378495 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature