Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache.

ABSTRACT: Cortical spreading depolarization (CSD), the neurophysiological event believed to underlie aura, might trigger migraine headaches through inflammatory signalling that originates in neurons and spreads to the meninges via astrocytes. Increasing evidence from studies on rodents and migraine patients supports this hypothesis. The transition from pro-inflammatory to anti-inflammatory mechanisms is crucial for resolving inflammation. However, the resolution of inflammation in the context of CSD and migraine headaches remains poorly understood. This study aims to elucidate the progression of post-CSD inflammatory signalling and its resolution in neurons, astrocytes and microglia in mouse brains. CSD was triggered optogenetically or by pinprick. High mobility group box 1 release, caspase-1 activa

SUBMITTER: Kaya Z 

PROVIDER: S-EPMC12378585 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature