Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression.

ABSTRACT: Cancer remains a leading cause of mortality worldwide, characterized by complex genetic and molecular alterations. The Protein Tyrosine Phosphatase Non-Receptor Type 6 (PTPN6), also known as SHP-1, plays a critical role in regulating immune responses and cellular signaling pathways, with emerging evidence suggesting its involvement in cancer progression. Previous studies have linked aberrant PTPN6 expression to tumorigenesis in specific cancers, such as lymphoma and leukemia, where it acts as a tumor suppressor. However, the comprehensive role of PTPN6 across pan-cancer, particularly its prognostic significance and molecular functions, has not been fully elucidated. This study aimed to provide a pan-cancer analysis of PTPN6, utilizing data from multiple public databases with molecular in v

SUBMITTER: Wang X 

PROVIDER: S-EPMC12378822 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature