Molecular profiles of the great obstetrical syndromes reveal common features and dynamic changes in early pregnancy.

ABSTRACT: The great obstetrical syndromes (GOS) encompass a spectrum of pregnancy-related complications that are the major determinants of maternal and neonatal mortality. Although shared placental pathology underlies these complications, knowledge of the molecular commonalities before clinical presentation remains incomplete. In this case-control study nested within the prospective Shanghai Birth Cohort, we investigated the molecular characteristics underlying GOS conditions in the pre-symptomatic phase using serum samples from 203 nulliparas who subsequently developed GOS and 181 controls. A multi-omics approach combining protein, metabolite, and gene analysis was employed. Here we show a shared molecular background of the spectrum of all tested GOS conditions at the co-expression module, molecule

SUBMITTER: Zeng X 

PROVIDER: S-EPMC12378939 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature