HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling.

ABSTRACT: The cranial base synchondrosis (CBS) is a critical growth center in the craniofacial region, and its abnormal development can lead to various craniofacial deformities. In a hypoxic microenvironment, hypoxia-inducible factor-1α (HIF-1α) is a crucial regulatory factor for cellular adaptation to low oxygen conditions. However, the role of HIF-1α in the CBS and its mechanisms regulating the function of chondrocytes remain unclear. This study aims to investigate the expression characteristics of HIF-1α in the CBS and its potential mechanisms in regulating mouse spheno-occipital synchondrosis (SOS) chondrocytes (SOSCs). Histological and immunohistochemical staining were utilized to observe the growth pattern of the SOS and the expression characteristics of HIF-1α in the SOS of 1-8 week-old mice.

SUBMITTER: Liang C 

PROVIDER: S-EPMC12378986 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature