Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal.

ABSTRACT: Phenobarbital monotherapy is increasingly used to treat alcohol withdrawal syndrome (AWS) in hospitalized patients, but its implementation outside academic emergency departments (EDs) and intensive care units (ICUs) remains understudied. To evaluate the implementation, clinical outcomes, and safety of an electronic health record (EHR) order set for intravenous weight-based phenobarbital loading (10 or 15 mg/kg) across all care locations (ED, acute care, and ICU) of a community hospital. This retrospective quality improvement study was conducted at a 281-bed community hospital in Seattle, Washington, including all hospitalized adults treated for AWS 11 months before and 12 months after implementation of the phenobarbital EHR order set (April 1, 2021, to March 31, 2023). Data analysis occurr

SUBMITTER: Wolpaw BJ 

PROVIDER: S-EPMC12379078 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature