Personalized Transcranial Direct Current Stimulation for Behavioral and Neurophysiologic Outcomes.

ABSTRACT: Transcranial direct current stimulation (tDCS) is emerging as a home-based intervention for neuropsychiatric conditions and cognitive enhancement. However, its effectiveness is limited by interindividual variability, as fixed-dose protocols have failed to account for anatomic differences influencing current delivery to targeted regions and treatment outcome. While computational modeling supports individualized dosing to improve consistency, experimental validation remains limited. To compare the behavioral and neurophysiologic outcomes of fixed-dose vs individualized-dose tDCS. This comparative effectiveness study using a within-participant, double-masked, crossover design was conducted from January 1, to March 31, 2024, at the National Institute of Mental Health and Neurosciences in India

SUBMITTER: Bhattacharjee S 

PROVIDER: S-EPMC12379099 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature