Identifying potential drug targets for postoperative abdominal wall hernia using Mendelian randomization: a multi-omics study.

ABSTRACT: This study aims to identify potential drug targets for postoperative abdominal wall hernia. Mendelian Randomization (MR) was applied to integrate data from druggable gene libraries, cis-pQTL data, and cis-eQTL data to analyze postoperative abdominal wall hernia in the FinnGen R11 population. Sensitivity and heterogeneity tests were conducted, along with reverse causality validation, to explore potential drug targets. A colocalization analysis was performed based on three cis-pQTL databases and cis-eQTL databases. Linkage disequilibrium was verified using Summary Data-Based Mendelian Randomization (SMR), and potential drug side effects were assessed using existing databases. Finally, drug target predictions and molecular docking studies were conducted. MR analysis revealed that, within the

SUBMITTER: Sun C 

PROVIDER: S-EPMC12379127 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature