Identification of potential drug targets and possible drugs for esophageal carcinoma from genetic insights: a comprehensive two-sample Mendelian randomization study.

ABSTRACT: Esophageal carcinoma (EC) is the eighth most common cancer, which is a major health problem on a global scale. Comprehensive treatments such as surgery, radiotherapy and chemotherapy have demonstrated efficacy in certain patients with early-stage esophageal carcinoma. However, it is crucial to explore improved treatment modalities for individuals with advanced, recurrent and metastatic esophageal carcinoma. The eQTL datasets were obtained from Drug-Gene Interaction Database (DGIdb V.4.2.0) and an interesting review about druggable genes. The two-sample MR was used to identify potential drug targets. Co-localization analysis was applied to evaluate if the genes expression single nucleotide polymorphisms (SNPs) drove and was associated with EC risk. And drug prediction and molecular docking

SUBMITTER: Wang J 

PROVIDER: S-EPMC12379196 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature