Gene expression profiling in cardiac tissue of mice chronically infected with Toxoplasma gondii: implications for immune response pathways.

ABSTRACT: Toxoplasma gondii is a common and opportunistic protozoan in vertebrates. Most cases of infection are asymptomatic, but in individuals with an immune system deficiency, it can cause severe complications. The parasite has the ability to form cysts in the host's heart, brain, and other tissues. Heart tissue damage during toxoplasmosis infection is associated with many complications, such as myocarditis, pericarditis, arrhythmia and heart failure. The parasite can survive and create a chronic form of infection by changing the expression of genes effective in the immune system. Therefore, the present study aims to investigate expression dynamics of candidate genes in the heart tissue of mice infected with the chronic T. gondii strain of Tehran and the pathways involved. After causing toxoplasm

SUBMITTER: Asadi M 

PROVIDER: S-EPMC12379302 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature