Calreticulin in the nasal mucus promotes neutrophil migration and pathogen clearance.

ABSTRACT: The nasal cavity harbors diverse microbiota, and the nasal mucosal innate defense against microbial infiltration is crucial for respiratory infections. Both the nasal mucus covering the surface of the nasal cavity and the neutrophils beneath the nasal epithelia are the first line of innate defense against pathogens. Studying nasal mucus is challenging because of difficulties in collecting stable, high-quality samples from humans. Here, we investigated how nasal mucus cooperates with neutrophils to exert antimicrobial effects. Nasal mucus proteins, derived from nasal mucosal explants of goats, can promote neutrophil migration and increase their bactericidal activity. Calreticulin, identified from total mucus proteins, triggered ICAM-1-dependent transendothelial migration of neutrophils. Mor

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12379368 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature