Gender-specific associations of blood immune markers with symptoms and cognitive function in major depressive disorder: a cross-sectional observational study.

ABSTRACT: Cognitive impairments constitute a core manifestation of major depressive disorder (MDD), albeit the precise mechanisms governing these impairments remain elusive. Inflammation may contribute to cognitive impairment and clinical symptoms in MDD. We conducted an investigation into the inflammatory markers present in patients with MDD, including white blood cell (WBC) counts, monocytes, lymphocytes, neutrophils, platelets, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), and their associations with symptoms and cognitive performance. A cohort comprising 95 patients diagnosed with MDD and 65 healthy controls (HCs) was enrolled. Clinical symptomatology was evaluated utilizing the Hamilton Depression Rating Scale (HAMD) and the Ha

SUBMITTER: Yang D 

PROVIDER: S-EPMC12379383 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature