Bacteroides dorei RX2020-derived bile acid alleviates influenza virus infection through TGR5 signaling.

ABSTRACT: The role of the gut microbiome in respiratory infections is increasingly recognized. We have found that a gut commensal strain, Bacteroides dorei RX2020 (B. dorei) previously isolated from healthy human fecal microbiota, alleviates influenza virus infection, but the underlying mechanisms remain elusive. To explore the mechanism by which B. dorei alleviates influenza, we administered it via gavage to influenza virus-infected mice. Gene knockout mice were then used to verify the underlying signaling pathways involved in the antiviral action of B. dorei. Metabolomics analysis was conducted to identify effective metabolites of B. dorei against influenza, followed by complementary verification to confirm these metabolites. Metabolomics reveals that influenza virus infection significantly reduce

SUBMITTER: He S 

PROVIDER: S-EPMC12379461 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature